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Review

“Hughes has crafted an engaging historical account of Genentech from its beginnings as a small laboratory at the University of California, San Francisco to the 2009 merger with Roche for 47 billion dollars. . . . [Her] account will appeal to a broad audience and is a must read for scholars interested in the history of biotechnology. Highly recommended.” (J. A. Hewlett Choice)“[A]n important addition to the history of biotech.” (Phillip A. Sharp, Massachusetts Institute of Technology Nature Medicine)“Over the past 20 years Sally Smith Hughes has done a great service to science studies by conducting in-depth oral-history interviews with prominent scientists, venture capitalists, corporate leaders, and attorneys in the history and business of early biotechnology. She drew on her unprecedented access to corporate records and a large number of actors and their oral histories to write Genentech, the first comprehensive account of the creation and early development of the Genentech Corporation.” (Doogab Yi Chemical Heritage Magazine)“The author skillfully reveals the practical, day-to-day, hands-on roles played by venture capitalists focused on fiscal gain and scientists focused on scientific breakthroughs. . . . [A] fascinating read.” (Valerie McGurk Nursing Standard)“[A]n eminently readable (and, for classes, eminently assignable) story . . . . Smith Hughes is one of the foremost oral historians of science today, and Genentech is filled with illuminating interview snippets woven artfully into a narrative that both engages and (somewhat surreptitiously) analyzes. . . . [F]or a case study that lays out in lively detail the ambiguities and exuberances of high-tech entrepreneurship, Smith Hughes’s Genentech surely ranks among the very best.” (Cyrus C. M. Mody, Rice University Bulletin of the History of Medicine)“[A] fascinating book, vividly recount[ing] the blood, sweat, and tears of the early days of ‘genetic engineers’ working at the bench, designing new biomolecules, and capitalizing their promises on Wall Street.” (Social History of Medicine)“Genentech: The Beginnings of Biotech paints a wonderfully detailed picture of an important beginning in the history of biotechnology.” (Nathan Crowe, Arizona State University Journal of the History of Biology)“Hughes’s Genentech makes an invaluable international contribution to understanding how a period just short of a decade redefined ‘business as usual’ for biologists.” (Lisa Onaga, Nanyang Technological University Technology and Culture)"Sally Smith Hughes skillfully describes the improbable creation, difficult adolescence, immense prosperity, and eventual foundering of Genentech, the first biotech behemoth. It’s a great tale, with a cast of fabulous characters and surprising episodes, ranging from Palo Alto to Wall Street. This is an outstanding book that should appeal to Nobel laureates as well as hedge-fund barons and ordinary citizens.” (Daniel S. Greenberg, author of Science for Sale and Tech Transfer)“Drawing extensively on oral histories, Hughes reveals the day-to-day hands-on roles of both the venture capitalists and the scientists, their eyes fixed at once on scientific triumphs and corporate riches, who brought Genentech to life. Hughes vividly recounts the tough-minded deals, buccaneering strategies, laboratory struggles, and relentless patent arrangements that not only made for Genentech’s success but that pioneered the new biotechnology industry’s operational model.” (Daniel Kevles, Yale University)

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About the Author

Sally Smith Hughes is a historian of science at the Bancroft Library at the University of California, Berkeley. She is the author of The Virus: A History of the Concept and the creator of an extensive collection of in-depth oral histories on bioscience, biomedicine, and biotechnology.

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Product details

Series: Synthesis

Paperback: 230 pages

Publisher: University of Chicago Press; Reprint edition (April 8, 2013)

Language: English

ISBN-10: 9780226045511

ISBN-13: 978-0226045511

ASIN: 022604551X

Product Dimensions:

6 x 0.6 x 9 inches

Shipping Weight: 14.4 ounces (View shipping rates and policies)

Average Customer Review:

4.7 out of 5 stars

24 customer reviews

Amazon Best Sellers Rank:

#262,463 in Books (See Top 100 in Books)

Vivid account of Genentech's founding and the early travails of the biotech industry.Things that would not immediately spring to mind today, like the deep suspicion or outright hostility of academic scientists to scientists who had an interest in business, or the paranoia surrounding the early days of genetic engineering, even in the scientific community.Somewhat uncritical acceptance of a "testosterone-charged atmosphere" as a key component of their success. Anybody who's worked with accomplished women scientists knows drive and ambition do not depend on one hormone!

My reading of Genentech follows my reading Science lessons abotu Amgen and this is a review I published elsewhere (my blog) os apologies for any inconsistency...I have to admit I had never heard of the Bancroft Library’s website (http://bancroft.berkeley.edu/ROHO/pro...) for the Program in Bioscience and Biotechnology Studies, “which centerpiece is a continually expanding oral history collection on bioscience and biotechnology [with ] in-depth, fully searchable interviews with basic biological scientists from numerous disciplines; with scientists, executives, attorneys, and others from the biotechnology industry.”The invention of new research and business practices over a very short periodSwanson was captivated: “This idea [of genetic engineering] is absolutely fantastic; it is revolutionary; it will change the world; it’s the most important thing I have ever heard.” [… But Swanson was nearly alone.] “Cetus was not alone in its hesitation regarding the industrial application of recombinant DNA technology. Pharmaceutical and chemical corporations, conservative institutions at heart, also had reservations.” [Page 32] “Whatever practical applications I could see for recombinant DNA… were five to ten years away, and, therefore, there was no rush to get started, from a scientific point of view.” [Page 32] “I always maintain” Boyer reminisced, “that the best attribute we had was our naïveté… I think if we had known about all the problems we were going to encounter, we would have thought twice about starting… Naïveté was the extra added ingredient in biotechnology.” [Page 36]The book shows the importance of scientific collaborations. Not just Boyer at UCSF but for example with a hospital in Los Angeles. A license was signed with City of Hope Hospital with a 2% royalty on sales on products based on the licensed technology. “[…] negotiated an agreement between Genentech and City of Hope that gave Genentech exclusive ownership of any and all patents based on the work and paid the medical center a 2 percent royalty on sales of products arising from the research.” [Page 57]Even if in 2000, City of Hope had received $285M in royalties, it was not happy with the outcome. After many trials, the California Supreme Court in 2008 awarded another $300M to City of Hope. So the book shows that these collaborations gave also much legal litigation. [Page 58]In a few years, Genentech could synthesize somatostatin, insulin, human growth hormone and interferon. It is fascinating to read how intense, uncertain, stressful these years were for Swanson, Perkins, Boyer and the small group of Genentech employees and academic partners (Goeddel, Kleid, Heyneker, Seeburg, Riggs, Itakura, Crea), in part because of the emerging competition from other start-ups (Biogen, Chiron) and academic labs (Harvard, UCSF).“On August 25, 1978 – four days after Goeddel’s insulin chain-joining feat – the two parties signed a multimillion-dollar, twenty-year research and development agreement. For an upfront licensing fee of $500,000, Lilly got what it wanted: exclusive worldwide rights to manufacture and market human insulin using Genentech’s technology. Genentech was to receive 6 percent royalties and City of Hope 2 percent royalties on product sales.” [Page 94] They managed to negotiate a contractual condition limiting Lilly’s use of Genentech’s engineered bacteria to the manufacture of recombinant insulin alone. The technology would remain Genentech’s property, or so they expected. As it turned out, the contract, and that clause in particular, became a basis for a prolonged litigation. In 1990, the courts awarded Genentech over $150 million in a decision determining that Lilly had violated the 1978 contract by using a component of Genentech’s insulin technology in making its own human growth hormone product. [Page 95] Perkins believed that the 8 percent royalty rate was unusually high, at a time when royalties on pharmaceutical products were along the lines of 3 or 4 percent. “It was kind of exorbitant royalty, but we agreed anyway – Lilly was anxious to be first (with human insulin)” […]The big company – small company template that Genentech and Lilly promulgated in molecular biology would become a prominent organizational form in a coming biotechnology industry. [Page 97]The invention of a new cultureYoung as Swanson was, he kept everyone focused on product-oriented research. He continued to have scant tolerance for spending time, effort, and money on research not tied directly to producing marketable products. “We were interested in making something usable that you could turn into a drug, inject in humans, take to clinical trials.” A few year before his premature death, Swanson remarked, “I think one of the things I did best in those days was to keep us very focused on making a product.“ His goal-directed management style differed markedly from that of Genentech’s close competitors. [Page 129]But at the same time Boyer would guarantee a high quality research level by encouraging employees to write the best possible scientific articles. This guaranteed the reputation of Genentech in the academic world.A culture was taking shape at Genentech that had no exact counterpart in industry or academia. The high-tech firms in Silicon Valley and along Route 128 in Massachusetts shared its emphasis on innovation, fast-moving research, and intellectual property creation and protection. But the electronics and computer industries, and every other industrial sector for that matter, lacked the close, significant, and sustained ties with university research that Genentech drew upon from the start and that continue to define the biotechnology industry of today. Virtually every element in the company’s research endeavor – from its scientists to its intellectual and technological foundations – had originated in decade upon decade of accumulated basic-science knowledge generated in academic labs. […] At Boyer’s insistence, the scientists were encouraged to publish and engage in the wide community of science. [Page 131]But academic values had to accommodate corporate realities: at Swanson’s insistence, research was to lead to strong patents, marketable products, and profit. Genentech’s culture was in short a hybrid of academic values brought in line with commercial objectives and practices. [Page 132]Swanson was the supportive but insistent slave driver, urging on employees beyond their perceived limits: “Bob wanted everything. He would say, If you don’t have more things on your plate than you can accomplish, then you’re not trying hard enough. He wanted you to have a large enough list that you couldn’t possibly get everything done, and yet he wanted you to try.” […] Fledging start-ups pitted against pharmaceutical giants could compete mainly by being more innovative, aggressive, and fleet of foot. Early Genentech had those attributes in spades. Swanson expected – demanded – a lot of everyone. His attitude was as Roberto Crea recalled: “Go get it; be there first; we have to beat everybody else… We were small, undercapitalized, and relatively unknown to the world. We had to perform better than anybody else to gain legitimacy in the new industry. Once we did, we wanted to maintain leadership.” […] As Perkins said “Bob would never be accused of lacking a sense of urgency. “ […] Even Ullrich, despite European discomfort with raucous American behavior, admitted to being seduced by Genentech’s unswervingly committed, can-do culture. [Page 133]New exit strategiesInitially Kleiner thought Genentech would be acquired by a major pharma company. It was just a question of when. He approached Johnson and Johnson and “floated the idea of a purchase price of $80 million. The offer fell flat. Fred Middleton [Genentech’s VP of finance], present at the negotiations, speculated that J&J didn’t have “a clue about what to do with this [recombinant DNA] technology – certainly didn’t know what it was worth. They couldn’t fit it in a Band-Aid mold”. J&J executives were unsure how to value Genentech, there being no standard for comparison or history of earnings.” [Page 140]Perkins and Swanson made one more attempt to sell Genentech. Late in 1979, Perkins, Swanson, Kiley and Middleton boarded a plane for Indianapolis to meet with Eli Lilly’s CEO and others in top management. Perkins suggested a selling price of $100 million. Middleton’s view is that Lilly was hamstrung by a conservative “not invented here” mentality, an opinion supported by the drug firm’s reputation for relying primarily on internal research and only reluctantly on outside contracts. The company’s technology was too novel, too experimental, too unconventional for a conservative pharmaceutical industry to adopt whole-heartedly. [Page 141]When Genentech successfully developed interferon, a new opportunity happened. Interferon had been discovered in 1957 and thought to prevent virus infection. In November 1978, Swanson signed a confidential letter of intent with Hoffmann – La Roche and a formal agreement in January 1980. They were also lucky: “Heyneker and a colleague attended a scientific meeting in which the speaker – to everyone’s astonishment given the field’s intense competitiveness – projected a slide of a partial sequence of fibroblast interferon. They telephoned the information to Goeddel, who instantly relay the sequence order to Crea. […] Crea started to construct the required probes. […] Goeddel constructed a “library” of thousands upon thousands of bacterial cells, seeking ones with interferon gene. Using the partial sequence Pestka retrieved, Goeddel cloned full-length DNA sequences for both fibroblast and leukocyte interferon. […] In June 1980, after filing patent protection, Genentech announced the production in collaboration with Roche.” [Page 145] Genentech could consider going public and after another fight between Perkins and Swanson, Genentech decided to do so. Perkins had seen that the year 1980 was perfect for financing biotech companies through a public offering but Swanson saw the challenges this would mean for a young company with nearly no revenue or product.New role modelsThe 1980-81 period would see the creation of a fleet of entrepreneurial biology-based companies – Amgen, Chiron, Calgene, Molecular Genetics, Integrated Genetics, and firms of a lesser note – all inspired by Genentech’s example of a new organizational model for biological and pharmaceutical research. Before the IPO window closed in 1983, eleven biotech companies in addition to Genentech and Cetus, had gone public*. […] But not only institutions were transformed. Genentech’s IPO transformed Herb Boyer, the small-town guy of blue-collar origins, into molecular biology’s first industrial multimillionaire. For admiring scientists laboring at meager academic salaries in relative obscurity, he became a conspicuous inspiration for their own research might be reoriented and their reputation enhanced. If unassuming Herb – just a guy from Pittsburgh, as a colleague observed – could found a successful company with all the rewards and renown that entailed, why couldn’t they? [Page 161]*: According to one source, the companies staging IPO were Genetic Systems, Ribi Immunochem, Genome Therapeutics, Centocor, Bio-Technology General, California Biotechnology, Immunex, Amgen, Biogen, Chiron, and Immunomedics. (Robbins-Roth, From Alchemy To Ipo: The Business Of Biotechnology)

The title pretty well explains the subject of Genentech. Hughes does not spare scientific detail, but she writes about it deftly, blending the science into the narrative. Readers with even the most basic understanding of genetics will hardly notice that they have gotten a short lesson on recombinant technology along with a great story.

The story of Genentech is pretty astounding. I have followed this company for a number of years. This company warranted the book, duly named. It was somewhat sensationalized, but easy to read and understand, even for someone with no ties or connection to the industry. I literally read it on a flight from la to san francisco including the time spent in the airport before takeoff. It was a great flight.

The book covers the beginnings of Genentech and serves as a useful case study for the biotech industry - a great resource for all the biotech startups today.

A well-paced and thoughtful history that successfully balances the personalities, drama, economics and science of the topic.

It is a very well written, interesting to read and learn as was creating one of the leading biotech companies book. From here begins another story. I recommend to read and use in teaching and research

Excellent

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Audible Audiobook

Listening Length: 12 hours and 8 minutes

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Publisher: SmartPass

Audible.com Release Date: October 28, 2009

Language: English, English

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PDF Download The Algorithmic Leader: How to Be Smart When Machines Are Smarter Than You, by Mike Walsh

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Review

“Provocative, powerful, and full of actionable wisdom. The Algorithmic Leader is a tour de force of ideas and insights from global pioneers who are challenging the status quo and reinventing organizations. Mike Walsh has produced a must-read for every leader and entrepreneur in this digital age.”―Daniel Hulme, Founder & CEO of Satalia"This book first made me deeply uneasy, and then deeply inspired. Like you, I wrestle with how best to thrive as our world grows increasingly complex and confusing, a world where the simple rules just don’t work anymore. Mike Walsh’s ten principles, distilled from real-life experience and deep thinking, point the way forward."―Michael Bungay Stanier, author of the Wall Street Journal bestseller The Coaching Habit“Great companies are built on culture. Mike Walsh’s prescient vision of the algorithmic company of the future is no robot army of soulless analytics dashboards, but a living, breathing organism―a community of humans who respond to motivation beyond compensation; purpose and impact; decision-making and autonomy; location and collaboration. A worthy read.”―Brian Halligan, Founder & CEO of Hubspot“Mike Walsh provides an interesting and informative look at our future, which will be defined by algorithms and artificial intelligence. The underlying technologies may seem complex, but the message for business leaders is simple: use the new tools to enhance your skills―or become roadkill.”―Vivek Wadhwa, Distinguished Fellow, Harvard Law School, Labor and Worklife Program and author of The Driver in the Driverless Car“Mike Walsh’s years of talking to the world’s technology leaders have given him unusually deep insight into the ways in which technology will change our world. Now he has written a powerful book that enables the rest of us to gain that insight. This book will change the way you think. Full of rich examples and great quotes, it is like a hyperspeed trip into the future that will give you a whole new perspective on your industry and career.”―Melissa Schilling, author of Quirky and Strategic Management of Technological Innovation“Mike Walsh’s The Algorithmic Leader is an intelligent and timely look at leadership in the digital age. If the twentieth century was governed by leaders of people, the twenty-first will be governed by leaders who understand the relationship between people and the technologies that define the modern workplace. Walsh exposes not just opportunities, but also potential pitfalls, ultimately leaving today’s leaders smarter and better prepared for the coming rise of algorithms and big data.”―Adam Alter, author of the New York Times bestseller Irresistible and Drunk Tank Pink“I have read many thousands of pages about the impact of algorithms and automation on our lives, and Mike Walsh’s The Algorithmic Leader stands out from the crowd. It is honest in its complexity, practical in its lessons, and profound in its analysis of the future of work. It’s a must-read for anyone contemplating how smart humans can collaborate with smart machines.”―David Epstein, author of the New York Times bestseller The Sports Gene and Range“The Algorithmic Leader is brilliant and scary. The scale of change that AI is bringing into our lives can be bewildering. In this timely book, Mike Walsh provides (often counterintuitive) ideas and fascinating insights into what the coming decades will bring. 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He paints a future for leadership that has a lot more in common with the art of gardening than the art of war. Great gardeners start with a great vision and then focus on creating an ecosystem that understands, nourishes, and tends, allowing all to become their strongest, no matter what uncertainties they face, until they brilliantly fruit and blossom. Walsh’s principles tell us how it should be done, but then he passionately shows that it is not the ‘how’ that matters but the ‘why’: to make our world a better place for all of humanity to flourish.”―Ali Parsa, founder & CEO of Babylon Health

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About the Author

Mike Walsh is the CEO of Tomorrow, a global consultancy on designing companies for the twenty-first century. He advises leaders on how to thrive in the current era of disruptive technological change. A true global nomad, Mike travels over 300 days a year worldwide, researching trends, collecting case studies, and presenting on the future of business. Mike's clients include many of the global Fortune 500, and as a sought-after keynote speaker he regularly shares the stage with world leaders and business icons alike. Mike previously founded Jupiter Research in Australia, and has also held senior strategy roles at News Corporation in the Asia Pacific region. Mike's other books include Futuretainment and The Dictionary of Dangerous Ideas. Each week he interviews provocative thinkers, innovators, and troublemakers on his podcast, Between Worlds.

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Product details

Hardcover: 256 pages

Publisher: Page Two (March 12, 2019)

Language: English

ISBN-10: 1989025331

ISBN-13: 978-1989025338

Product Dimensions:

6.5 x 1 x 9.2 inches

Shipping Weight: 1.2 pounds (View shipping rates and policies)

Average Customer Review:

5.0 out of 5 stars

4 customer reviews

Amazon Best Sellers Rank:

#27,321 in Books (See Top 100 in Books)

If technology and artificial intelligence seems complicated or confusing to you, then this is a must-read book from Mike Walsh’s futuristic vision. It is inspiring and groundbreaking for our present and future digital world whether you are an entrepreneur, business owner or just at the beginning of your career.Amazing story telling from the author and his interviews with some of the greatest leaders in their sectors. Definitely recommend this eye-opening book.

The authors insight on the future and how these new leadership principles apply, is literally uncanny. I think this book will ultimately become a “how to fly” manual for the modern leader. Great book!

This book was a gift from a friend. A great and thought provoking read as with many of the authors books and articles. Would highly recommend.

Great book! It is an invitation to see how the future is being created globally. AI will continue to disrupt business, but also to dig a social divide that only good education can close.

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